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 Treatment of Untreatable Hormone Deficiency Disorders  by BCRO fetal precursor cell transplantation

 

Several hormone deficiency disorders, where hormone replacement therapy could not re-establish a normal hormonal balance, have been helped by BCRO cell transplantation with increasing frequency.

(biocell@stem-cell-transplantation.com)

Besides diabetes mellitus there are other common hormonal diseases where the endocrine glands function is low, 

such as hypothyroidism, premature menopause, etc., 

in which BCRO cell transplantation may be necessary in patients who stopped responding properly to the standard hormone replacement therapy. 

Although some of these diseases, such as hypothyroidism, are as common as diabetes mellitus, the statistics of its incidence are not too accurate, 

because hypothyroidism is the cause of  death or seriously disabling complications only rarely, and its socio-economic significance is low.

It has been observed with increasing frequency nowadays that diseases with low function of endocrine glands respond to the hormone replacement therapy not as well as expected, even in hands of the best endocrinologist. 

At the same time physicians have been noticing more and more often that majority of patients diagnosed with hypothyroidism, or Addison disease (with low function of adrenal cortex), etc., developed such illnesses because of autoimmunity. 

This could explain a lower success rate of a classical hormone replacement therapy in such patients: 

  • the relentless progress of an autoimmune damage of hormone producing cells of the diseased endocrine gland ultimately leaves patient with very low quantity of functioning endocrine cells, 

  • so that even a high dosage of oral hormone pills cannot provide a patient with an adequate level of missing hormone,

  • but the competitive inhibition whereby the oral hormone therapy suppresses the function of patient’s own cells producing the same hormone may play a part.

 

The goal of BCRO cell transplantation in the treatment of such autoimmune diseases is 

  • mostly immunomodulation, e.g. normalization of immune system function, and thereby suppression of the autoimmune process, and 
     
  • a repair, or regeneration, of non-functioning hormone producing cells.
     

It is not a purpose of cell therapy to eliminate the need for hormone replacement therapy.

BCRO cell transplantation should aim at balancing  regulations of the 'axis hypothalamus – pituitary - peripheral endocrine gland (thyroid in hypothyroidism)', disturbed by years of disharmony and demands for over-compensation.  

Level of hormones has to be measured after cell transplantation much more frequently, and the dosage of oral hormones lowered accordingly, but as a rule their intake cannot be discontinued.

If we disregard diabetes mellitus, among hormone deficiency disorders the most common indication for BCRO cell transplantation in clinical practice has been a pronounced hypothyroidism, which is practically always a result of Hashimoto’s (autoimmune) thyroiditis. 

Thyroid hormones increase the anabolic processes in the body, activity of enzymes of the sodium pump and the breakdown of ATP, and of oxygen utilization, thereby increasing the basal metabolic rate and body temperature. They stimulate glycogenolysis, and gluconeogenesis, lipolysis and excretion of bile acids in bile. They sensitize adrenoreceptors and thereby increase the contractility of myocardial fibers and heart rate, stimulate intestinal motility, glomerular filtration rate and tubular transport in kidneys, and neuromuscular reaction treshold. They support intellectual development and growth of body in length and catabolism in bone

Without thyroid hormones there is no growth of dendrites, axons, and synapses, no glia development and no myelinization. If the condition is not recognized at birth and thyroid substitution started immediately, the ensuing brain damage gets beyond repair later on. Deafness and dwarfism accompany lack of brain development.

BCRO type of fetal precursor cell transplantation,  has been used successfully for 80+ years as treatment of many diseases
  • for which modern medicine has had no therapy (i.e. incurable), or
     
  • in which 'state-of-art' therapies stopped being effective (i.e. no longer treatable),

in documented over 5 millions of patients worldwide. Physicians can learn about it in a textbook by E. Michael Molnar, M.D.: Fetal Precursor Cell Transplantation, BCRO Fetal Precursor Cell Transplantation", published in 2014 by www.amazon.com
On the same web site the general readership can find out all about it in the book by the same author: “Treatment of Incurable and No Longer Treatable Diseases”, published in January 2015, as well as in his autobiography: “Diseases and Genocide are not Our Destiny”. You can buy it as 'free reader download for PC' as well as Kindle Book.

 

  (biocell@stem-cell-transplantation.com)

 

 

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Updated: March 2015