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 Treatment of Incurable Diseases of Central Nervous System, Brain and Spinal Cord Injuries, by BCRO Fetal Brain Cell Transplantation

Diseases of central nervous system, 100% incurable/untreatable  � with an exception of early Parkinson�s disease, temporarily treatable by L-Dopa � were successfully treated by IIBM, as a result of superb work of Prof.Dr. Saveliev and team of neurophysiologists from Russian Academy of Sciences, and of neurosurgeon Prof.Dr. Lebedev and his team from Sklifasovsky Institute of Emergency Medicine of Russian Academy of Medical Sciences, and our IIBM team, with me as a clinician and Dr. Alexander J. Anikin, a bright physician � scientist, devoting his complete dedication to the brain, in Moscow. This group of talented and dedicated people proved, that all patients with untreatable/incurable diseases of brain and spinal cord can be successfully treated by fetal brain cell transplantation.

Treatment of Parkinson�s disease in late 1980�s in Mexico City by neurosurgeon  Dr.I.Madrazo, and his team, and then in Sweden, Germany and U.S.A., by neurotransplantation, was noted by us, particularly the fact that their therapeutic success was only in 3 % patients, although in animal experiments it reached 95%.

Experiments of Saveliev and his team began in 1990 with search for reasons of a failure of work done in Mexico, Sweden, Germany and U.S.A: by transplantation of brain cells between vertebrates and non-vertebrates, as well as between various species of mammals. It proved that survival of animal fetal brain cell transplants in the host�s human brain was three times longer than in transplantation of human fetal brain cells, particularly when animal fetal brain transplantation was between genetically discordant species rather than concordant ones.

A meticulous research taught Saveliev and his team, first of all, that primordial brain cells of various genetic mutants of Drosophila melanogaster were very useful in neuro-transplantation into the brain of various vertebrates, including all mammals. Their exceptional success stemmed from the fact that Drosophila survival in mammalian brain was 3 months(!) The mixture of human fetal brain cells from ventral mesencephalon and basal ganglia with primordial brain cells of the genetic mutants of Drosophila melanogaster,  in  weight ratio 50:1, or higher, was prepared in laboratory and then implanted under stereoscopic control into ventrolateral thalamic nuclei of patients with Parkinson�s disease. Three of the several operated patients� case histories were described in a published report. After 12 months� follow-up there was no recurrence of Parkinson�s disease and overall success was 95%.

The genetic mutants of Drosophila melanogaster served as a stimulants for implanted human fetal brain cells          TO PROMOTE THEIR DIFFERENTIATION AND VASCULARIZATION and          GROWTH OF THE HOST�S NEURONAL PROCESSES TOWARD DONOR BRAIN CELL TRANSPLANTS                             as well as                                         STIMULATION OF  CIRCULATION IN ADJACENT HOST�S BRAIN TISSUE.

One of the eight patients of this series died of unrelated myocardial infarction 8 months later, and a full autopsy of his brain was carried out, that showed the reason for the complete success of described combined xeno-allo-fetal cell transplantation as a treatment of Parkinson�s disease. It is published by Saveliev.

Next, our extensive experimental work on transplantation of animal fetal brain cells in Moscow led to a discovery of clinical effectiveness of their intrathecal implantation(!). 

Then Saveliev and his team began search for reasons for major  failure of work done in Mexico, Sweden, Germany and U.S.A.

The initial findings were:

1)  in order to establish synaptic connection with host neurons, it is mandatory to transplant animal fetal brain cells with well known and pre-determined properties;   we learned that human fetal brain cells were not the only cells to accomplish that goal - on the contrary, the animal fetal brain cells were much more suitable for such purpose;

2)  transplanted cells must be highly metabolically active, and  here we learned, that human fetal brain cells alone cannot fulfill such requirement, other kinds of brain cells of non-human origin must be added;

3)  transplanted brain cells must be strongly genetically pre-set in their direction of differentiation.  

The implanted brain cell transplants must be alive (with a guarantee) in order to be therapeutically effective. Without life, there can be no success with fetal brain cell transplantation treatment!

A lot of information was obtained from more than 100 hopeless patients in coma due to gunshot wounds of the brain. They all were  treated by intrathecal implantation of fetal brain cell transplantation, and after their death, subjected to a detailed autopsy of the brain: nothing unusual was found, in particular there was no evidence of obstructive hydrocephalus, so that there was a complete patency of foramina Magendie and Luschkae.

For a comparison, in comatose patients with diseases of the brain the recovery after fetal brain cell transplantation was the usual outcome.

All this work was published, or reported at our First Symposium on Transplantation of Human Fetal Tissues: fundamental investigations and clinical practice, in December 4 � 7, 1995, in Moscow.

The initial published study of 14 patients, from 29 to 82 years of age, 4 with cerebro-vascular accidents, 4 with Parkinson�s disease, 2 with coma after clinical death for 18 days(both), one with toxic encephalopathy, 1 with vascular collapse, 1 with post-traumatic encephalopathy, 1 with Alzheimer�s disease, treated with intrathecal implantation of fetal brain cells, done in 1994-5.

The 14 patients reported on were hospitalized in Central Clinical Hospital- only for �nomenclatura�. Before this study started, there was two hour meeting with the director of the general hospital for 1500 patients, hidden in a forest of birch trees, where every detail was discussed by the 5 senior members of Department of Neurology and 2 doctors from IIBM � I was one of them. All patients had the highest security clearance, so no error was permitted.

First patient was a 29 years old mother of two, who 30 seconds after injection of Ampicillin developed anaphylactic shock. Resuscitation restored spontaneous breathing and improved cardiac function, but deep coma persisted. On 18^th day of coma human fetal brain cell transplantation by lumbar puncture was done. 18 hours later a patient opened her eyes, recognized her mother, was answering questions in simple words. Left-sided hemiparesis, urinary and fecal incontinence and dementia persisted. Gradual improvement was noted. 10 weeks later 2^nd intrathecal fetal brain cell transplantation was done. After two days a dramatic improvement was seen by everyone: athetoid movements of left hand and arm stopped, spasticity on the left side substantially diminished, improvement of speech, reading, writing, comprehension, gait, EEG, was observed.

Second patient, a 45 years old male, was undergoing uneventful surgery for retinal detachment, when a few minutes before the end a sudden bradycardia and blood pressure drop occurred. In recovery room the patient was in stupor, and akinesia with rigidity quickly developed. On 22^nd day the patient was transferred to a psychiatric ward for rehabilitation of psychic functions. On 25^th day an intrathecal transplantation of human fetal brain cells was done. Two days later a dramatic improvement took place: in particular of writing, drawing. Then 4 months later a 2^nd intrathecal transplantation of fetal brain cells was done followed by a continuous improvement.

Third patient was a 65 years old female who with a recent cerebrovascular accident. Intrathecal transplantation of human fetal brain cells was carried out immediately. There was a dramatic improvement, so that rehabilitation could begin already 18 hours later. Only 2 days later hemiplegia improved to level of minor hemiparesis. On 8^th day patient began to walk with walker.

Remaining 400+ patients with various untreatable neurological diseases were hospitalized in Navy Hospital in Kupavna, and treated by intrathecal implantation of human fetal brain cell transplantation in 1994 � 5. The report was read at the same above symposium. Overall there was an improvement in all(!) patients. 

IIBM treated by FCT also many patients in Qatar, where we had a personal support of (now retired) Emir of Qatar and his wife.  

IIBM�s success in Moscow in treatment of incurable diseases of central nervous system was further confirmed by myself, working alone from 1997 till 2016, in various countries of the world, also as my own physician.  I got a stroke, which was nearly terminal(!),  on August 22, 2016. Considering a state of my intellect I somehow managed to organize my own fetal brain cell transplantation on December 12, 2016: I wrote my own prescription for fetal brain cell transplants that were implanted in my brain by lumbar puncture, which was highly successful - in the opinion of my neurologists and everybody, who knew me well and meets me in person now. Today I can work again with my full(!) intellectual capacity.

Prior to my cerebro-vascular accident, in 1997 - 2016 I had phenomenal success in treatment of dementias,   including stage 4 of Alzheimer�s disease, by BCRO fetal brain cells transplantation via intrathecal implantation (by lumbar puncture). IIBM began to investigate treatment of dementias by fetal brain cell transplantation with Alzheimer�s Institute of huge 15^th Psychiatric Hospital in Moscow 1995, but we never got to treat actual patients with dementia with fetal brain cell transplantation.

On July 30, 2015, I did BCRO fetal brain cell transplantation (and FCT), at University Hospital of my Alma Mater in Bratislava, Slovakia, to my close friend, Dr. J.M., retired gynaecologist, fellow emigrant to U.S., two years before me, one of the members of Board of Directors of IIBM, for stage 4 of Alzheimer disease. He retired when he was 70 years old. He underwent - soon thereafter - 4 years long battle with cancer of colon with metastases. As a side effect of his cancer treatment, he got myocardial infarct with congestive heart failure and arrhythmia, and dementia.

Only 4 weeks after his FCT there was a dramatic improvement in level of vitality, depression and memory: when I met him 75 days after his departure (from Slovakia) in Los Angeles: he was happy, talkative, the way he was always known to me.

The treatment of incurable diseases of central nervous system has been the biggest success of our IIBM project in Moscow. We proved that the opinion of medical profession of the world that the diseases of central nervous system are untreatable and incurable � by definition � was and is wrong!

After basic research of Saveliev and his team, my further clinical research after my departure from Moscow was based on actual treatment of patients with advanced diseases of central nervous system with BCRO fetal brain cell transplantation all over the world.

I did a lot of intrathecal transplantations of fetal brain cells (originating from closed colony of rabbits) after my departure from Moscow in 1997. At the beginning most of the patients were from South Africa. This was a result of responding to SOS call from parents of a 19 years young man, who broke his neck after jumping in the swimming pool: he was completely paralyzed from head on down. I offered to treat a patient by fetal brain cell transplantation in South Africa, but the President Mbeki and ANC Minister of Health refused to give permission. Big media war was launched. With the cooperation of well known Rehabilitation Institute for Neurological Diseases in Bloemfontein, we treated in Germany 70 patients from South Africa, mostly with old injuries of spinal cord, but also of various diseases of brain. All these patients received the fetal brain cell transplantation by lumbar puncture. CT scan of all patients with injury of spinal cord showed a complete (!) transsection of spinal cord, and despite that in all but two, both over 50 years old, showed a significant improvement. Knowing the microscopic anatomy of spinal cord, such good results were totally un-explainable. One of those patients, a motorcycle rider, was able to race his motorcycle again. His erection came back as well.

All remaining male patients remained impotent, since the autonomous nervous system fibers responsible for control of sexual functions are located outside of spinal cord(!).  No one knows how to treat the injuries of peripheral portion of autonomous nervous system as yet.

A 31 year old physician, the rugby star in South Africa, son of a �society physician� in Pretoria, suffered a fracture of cervical spine in a car accident. He was operated on by a professor of neurosurgery of Pretoria Medical School. In the recovery room a patient developed a massive embolization of right carotid artery. He was taken back to the Operating Room. While an attempt was made to remove emboli, a new embolization of the left carotid artery took place. Following all these mishaps, patient was left with a �locked-in-syndrome�, total paralysis of all muscles in his body, with the sole exception of extra-ocular muscles. His neurosurgeon told parents, that the patient will never breathe on his own, speak or swallow. An intensive rehabilitation in South Africa for 12 months followed.

When the patient arrived in Germany, his breathing was shallow, he could not clear his bronchial secretions, could not swallow at all, was able to say a word only by squeezing the air out his lungs. All muscles in his body were paralyzed.

Five days after fetal brain cell transplantation the patient was able to stand up with assistance, cough up his bronchial secretions, speak, swallow and move his hands(!) Two months later he began his horseback riding training and could maintain balance in the saddle on his own. His speech dramatically improved, as well as swallowing and breathing. His eyesight improved, as to extra-ocular muscles function and accommodation.

In another one month, in May 2005, there was a conference at the medical school in Pretoria, Alma Mater of the patient, in my honor.  I gave a long lecture about fetal brain cell transplantation. The discussion afterward was chaired by the patient. He had to use some technical help to speak in the large auditorium, like Prof.Dr. Stephen Hawking, but his brain was functioning perfectly well.

A 46 years old male, a sportsman, from London, UK, in 1993 developed encephalitis, following which he lied in bed, motionless. No detailed diagnosis was ever made, no treatment offered. When he complained about lack of any therapy, he was sent to psychiatric ward, from where he was taken home by his wife, against medical advice. After metabolic preparation, in July 2002, in Kiel, Germany, he received BCRO intrathecal fetal brain transplantation. Three months later he was able to move with assistance and receive intensive physiotherapy program. One year later, he was able to walk a short distance and to do a self-care in a wheel-chair. In June 2004 the patient was walking without assistance. He gained weight. In October 2004, he became the father of a healthy boy. 

After my departure from Moscow in 1997 I treated additional patients by fetal brain cell transplantation in Germany, Slovakia, Czech Republic, Austria, Italy, Peoples� Republic of China, South Africa, India, Hong Kong, Indonesia, Turkey, Nigeria, Panama, Mexico, US, by myself, with following incurable/untreatable medical problems:

prolonged coma of various etiologies,                 incurable/untreatable Parkinson�s disease and syndrome,      amyotrophic lateral sclerosis,                                             neurodegenerative diseases, i.e. multiple sclerosis, Friedreich�s ataxia,                                                                                              neural muscular atrophies,                                                         Duchenne and Becker muscular dystrophies,                                myasthenia gravis,                cerebrovascular accidents (stroke), etc.                              

My first patient in Europe was an Austrian politician, a friend of my childhood female friend, a  physician. A patient with diabetes mellitus and a hypertension had 6 months earlier survived a major stroke, with residual hemiplegia and expressive aphasia. He was depressed due to his disability and persistent pain due to spasticity. I treated him with BCRO implantation of 3 different fetal brain cell transplants from rabbits (from the closed colony). His hemiplegia improved 50% and speech 70%. I treated also - at the same time �  his diabetes, hypertension by BCRO FCT (from the same rabbits). He was my first West European patient after leaving Moscow.

In 2007 I treated in Hong Kong a 91 years old man with Parkinson�s syndrome (the clinical picture of is the same as that of Parkinson�s disease, but the cause is arteriosclerosis of the Willis arterial circle at the base of the brain), dementia and depression. I treated him with the intrathecal fetal brain cells implantation, plus nine of BCRO FCT�s. In 2 months later, his son reported that 2 weeks ago his father told his valet to prepare his clothes, because he is going to casino at night (as that was his favored past time all of his adult life). There was no way to stop him. He spent most of the night in casino and he actually made some money! He was acting like 20 years younger. The fact that he dared to gamble and gambled successfully, was the best proof of success of his treatment, together with improvement of symptoms of Parkinson�s syndrome.

In 1988 I treated my medical school classmate, disabled by multiple sclerosis. She got the first attack of MS at the age of 26 right after her first pregnancy, as usually happens in women and in age of 33 she was totally disabled. Her FCT was done at the age of 56 when she was already terminal. She got better and wanted to live again to make her husband, a close friend of mine, happy. She died 20 years later in 2018. � In multiple sclerosis - under no circumstances - must not be fetal brain cells implanted in the brain!

Charcot-Marie-Tooth disease (in childhood) was successfully treated in Austria.                                                                                          

Amyotrophic lateral sclerosis is untreatable disease, where death will ensue within a few years from the onset. I treated 4 patients from South Africa.                                                                                           First patient was a male, who was treated twice by intrathecal fetal brain cell transplantation and observed to be well for 3 years.                  Second patient was a male, who received such a treatment once and was well for 2 years.                                                                         Third patient was a female and her ALS was progressing very fast. She was treated once the same way and her disease stopped for one year.   -                                                                                             Fourth patient was a male and his disease progressed even faster than in No. 3. He was treated once, and his disease stopped for one year. �                                                                                                      I did not have any further follow-up on all 4 patients.

Muscular dystrophies � 10 Duchenne  and 2 Becker patients � were treated by IIBM in Moscow and one I treated in Indonesia by BCRO FCT. The Duchenne patients showed only a minor improvement, while those with Becker had good result. One patient with Duchenne in Indonesia was older than patients with Moscow and the result was only mediocre.

Successful treatment of apallic syndrome in 35 children less than 12 years old was accomplished by cell therapy by my teacher Prof.Dr. Franz Schmid, after the death of Prof.Dr. Paul Niehans the next king of zellentherapie.