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List
of Diseases Treated by
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Treatment of Incurable Diseases of Central Nervous System, Brain and Spinal Cord Injuries, by BCRO Fetal Brain Cell Transplantation
Diseases of central nervous system, 100% incurable/untreatable
� with an exception of early
Parkinson�s disease, temporarily treatable by L-Dopa � were successfully
treated by IIBM, as a result of superb work of Prof.Dr. Saveliev and team
of neurophysiologists from Russian Academy of Sciences, and of
neurosurgeon Prof.Dr. Lebedev and his team from Sklifasovsky Institute of
Emergency Medicine of Russian Academy of Medical Sciences, and our IIBM
team, with me as a clinician and Dr. Alexander J. Anikin, a bright
physician � scientist, devoting his complete dedication to the brain, in
Moscow. This group of talented and dedicated people
proved, that all patients with untreatable/incurable diseases of
brain and spinal cord can be successfully treated by fetal brain cell
transplantation.
Treatment of Parkinson�s disease in late 1980�s in Mexico City by
neurosurgeon Dr.I.Madrazo, and his
team, and then in Sweden, Germany and U.S.A., by neurotransplantation, was
noted by us, particularly the fact that their therapeutic success was only
in 3 % patients, although in animal experiments it reached 95%.
Experiments of Saveliev and his team began in 1990 with search for reasons
of a failure of work done in Mexico, Sweden, Germany and U.S.A: by
transplantation of brain cells between vertebrates and non-vertebrates, as
well as between various species of mammals. It proved that
survival of animal fetal brain cell
transplants in the host�s human brain was three times longer than in
transplantation of human fetal brain cells, particularly when animal fetal
brain transplantation was between
genetically discordant species rather than concordant ones.
A meticulous research taught Saveliev and his team, first of all, that
primordial brain cells of various
genetic mutants of Drosophila melanogaster were very useful in
neuro-transplantation into the brain of various vertebrates, including all
mammals. Their exceptional success stemmed from the fact that
Drosophila survival in mammalian brain was 3 months(!) The mixture of
human fetal brain cells from ventral mesencephalon and basal ganglia
with primordial brain cells of
the genetic mutants of Drosophila melanogaster,
in weight ratio 50:1, or
higher, was prepared in laboratory and then implanted under stereoscopic
control into ventrolateral thalamic nuclei of patients with Parkinson�s
disease. Three of the several operated patients� case histories were described in
a published report. After 12 months� follow-up there was no recurrence
of Parkinson�s disease and overall success was 95%.
The genetic mutants of Drosophila melanogaster served as a stimulants for
implanted human fetal brain
cells TO PROMOTE THEIR
DIFFERENTIATION AND VASCULARIZATION and
GROWTH OF THE HOST�S NEURONAL PROCESSES TOWARD DONOR BRAIN
CELL TRANSPLANTS
as well as
STIMULATION OF CIRCULATION
IN ADJACENT HOST�S BRAIN TISSUE.
One of the eight patients of this series died of unrelated myocardial
infarction 8 months later, and a full autopsy of his brain was carried
out, that showed the reason for the complete success of described combined
xeno-allo-fetal cell transplantation as a treatment of Parkinson�s
disease. It is published by Saveliev.
Next, our extensive experimental work on transplantation of
animal fetal brain cells in Moscow led to a discovery of clinical
effectiveness of their intrathecal implantation(!).
Then Saveliev and his team began search for reasons for major
failure of work done in Mexico,
Sweden, Germany and U.S.A.
The initial findings were:
1)
in
order to establish synaptic connection with host neurons, it is mandatory
to transplant animal fetal brain cells with well known and pre-determined
properties;
we learned that human fetal brain
cells were not the only cells to accomplish that goal - on the contrary,
the animal fetal brain cells were much more suitable for such purpose;
2)
transplanted cells must be highly metabolically active,
and here we learned, that
human fetal brain cells alone cannot fulfill such requirement,
other kinds of brain cells of non-human origin must be added; 3) transplanted brain cells must be strongly genetically pre-set in their direction of differentiation.
The implanted brain cell transplants must be alive (with a guarantee) in
order to be therapeutically effective. Without life, there can be no
success with fetal brain cell transplantation treatment! A lot of information was obtained from more than 100 hopeless patients in coma due to gunshot wounds of the brain. They all were treated by intrathecal implantation of fetal brain cell transplantation, and after their death, subjected to a detailed autopsy of the brain: nothing unusual was found, in particular there was no evidence of obstructive hydrocephalus, so that there was a complete patency of foramina Magendie and Luschkae.
For a comparison, in comatose patients with diseases of the brain the
recovery after fetal brain cell transplantation was the usual outcome.
All this work was published, or reported at our First Symposium on
Transplantation of Human Fetal Tissues: fundamental investigations and
clinical practice, in December 4 � 7, 1995, in Moscow.
The initial published study of 14 patients, from 29 to 82 years of age, 4
with cerebro-vascular accidents, 4 with Parkinson�s disease, 2 with coma
after clinical death for 18 days(both), one with toxic encephalopathy, 1
with vascular collapse, 1 with post-traumatic encephalopathy, 1 with
Alzheimer�s disease, treated with intrathecal implantation of fetal brain
cells, done in 1994-5.
The 14 patients reported on were hospitalized in Central Clinical
Hospital- only for �nomenclatura�. Before this study started, there was
two hour meeting with the director of the general hospital for 1500
patients, hidden in a forest of birch trees, where every detail was
discussed by the 5 senior members of Department of Neurology and 2 doctors
from IIBM � I was one of them. All patients had the highest security
clearance, so no error was permitted.
First patient was a 29 years old mother of two, who 30 seconds after
injection of Ampicillin developed anaphylactic shock. Resuscitation
restored spontaneous breathing and improved cardiac function, but deep
coma persisted. On 18th
day of coma human fetal brain cell transplantation by lumbar puncture was
done. 18 hours later a patient opened her eyes, recognized her mother,
was answering questions in simple words. Left-sided hemiparesis, urinary
and fecal incontinence and dementia persisted. Gradual improvement was
noted. 10 weeks later 2nd intrathecal fetal brain cell
transplantation was done. After two days a dramatic improvement was
seen by everyone: athetoid movements of left hand and arm stopped,
spasticity on the left side substantially diminished, improvement of
speech, reading, writing, comprehension, gait, EEG, was observed.
Second patient, a 45 years old male, was undergoing uneventful surgery for
retinal detachment, when a few minutes before the end a sudden bradycardia
and blood pressure drop occurred. In recovery room the patient was in
stupor, and akinesia with rigidity quickly developed. On 22nd
day the patient was transferred to a psychiatric ward for rehabilitation
of psychic functions. On 25th
day an intrathecal transplantation of human fetal brain cells was done.
Two days later a dramatic improvement took place: in particular of
writing, drawing. Then 4 months
later a 2nd intrathecal transplantation of fetal brain cells
was done followed by a continuous improvement.
Third patient was a 65 years old female who with a recent cerebrovascular
accident. Intrathecal
transplantation of human fetal brain cells was carried out immediately.
There was a dramatic improvement, so that rehabilitation could begin
already 18 hours later. Only 2 days later hemiplegia improved to level of
minor hemiparesis. On 8th day patient began to walk with
walker.
Remaining 400+ patients with various untreatable neurological diseases
were hospitalized in Navy Hospital in Kupavna, and treated by intrathecal
implantation of human fetal brain cell transplantation in 1994 � 5. The
report was read at the same above symposium. Overall there was an
improvement in all(!) patients.
IIBM treated by FCT also many patients in Qatar, where we had a personal
support of (now retired) Emir of Qatar and his wife.
IIBM�s success in Moscow in treatment of incurable diseases of central
nervous system was further confirmed by myself,
working alone from 1997 till 2016,
in various countries of the world,
also as my own physician.
I got a stroke, which was nearly
terminal(!), on August 22, 2016.
Considering a state of my intellect I somehow managed to organize my own
fetal brain cell transplantation on December 12, 2016: I wrote my own
prescription for fetal brain cell transplants that were implanted in my
brain by lumbar puncture, which was highly successful - in the opinion of
my neurologists and everybody, who knew me well and meets me in person
now. Today I can work again with my full(!) intellectual capacity.
Prior to my cerebro-vascular accident,
in 1997 - 2016 I had phenomenal
success in treatment of dementias, including
stage 4 of Alzheimer�s disease, by BCRO fetal brain cells transplantation
via intrathecal implantation (by lumbar puncture). IIBM began to
investigate treatment of dementias by fetal brain cell transplantation
with Alzheimer�s Institute of huge 15th Psychiatric Hospital in
Moscow 1995, but we never got to treat actual patients with dementia with
fetal brain cell transplantation.
On July 30, 2015, I did BCRO fetal brain cell transplantation (and FCT),
at University Hospital of my Alma Mater in Bratislava, Slovakia, to my
close friend, Dr. J.M., retired gynaecologist, fellow emigrant to U.S.,
two years before me, one of the members of Board of Directors of IIBM,
for stage 4 of Alzheimer disease.
He retired when he was 70 years old. He underwent - soon thereafter - 4
years long battle with cancer of colon with metastases. As a side effect
of his cancer treatment, he got myocardial infarct with congestive heart
failure and arrhythmia, and
dementia.
Only 4 weeks after his FCT there was a dramatic improvement in level of
vitality, depression and memory: when I met him 75 days after his
departure (from Slovakia) in Los Angeles: he was happy, talkative, the way
he was always known to me.
The treatment of incurable diseases of central nervous system has been the
biggest success of our IIBM project in Moscow. We proved that the opinion
of medical profession of the world that the diseases of central nervous
system are untreatable and incurable � by definition � was and is wrong!
After basic research of Saveliev and his team,
my further clinical research after
my departure from Moscow was based on actual treatment of patients with
advanced diseases of central nervous system with BCRO fetal brain cell
transplantation all over the world.
I did a lot of intrathecal transplantations of fetal brain cells (originating
from closed colony of rabbits)
after my departure from Moscow in 1997. At the beginning most of the
patients were from South Africa. This was a result of responding to SOS
call from parents of a 19 years young man, who broke his neck after
jumping in the swimming pool: he was completely paralyzed from head on
down. I offered to treat a patient by fetal brain cell transplantation in
South Africa, but the President Mbeki and ANC Minister of Health refused
to give permission. Big media war was launched. With the cooperation of
well known Rehabilitation Institute
for Neurological Diseases in Bloemfontein, we treated in Germany
70 patients from South Africa, mostly with old injuries of spinal cord,
but also of various diseases of brain. All these patients received the
fetal brain cell transplantation by lumbar puncture. CT scan of all
patients with injury of spinal cord showed
a complete (!) transsection of
spinal cord, and despite that in all but two, both over 50 years old,
showed a significant improvement.
Knowing the microscopic anatomy
of spinal cord, such good results were totally un-explainable. One
of those patients, a motorcycle rider, was able to race his motorcycle
again. His erection came back as well. All remaining male patients remained impotent, since the autonomous nervous system fibers responsible for control of sexual functions are located outside of spinal cord(!). No one knows how to treat the injuries of peripheral portion of autonomous nervous system as yet.
A 31 year old physician, the rugby star in South Africa, son of a �society
physician� in Pretoria, suffered a fracture of cervical spine in a car
accident. He was operated on by a professor of neurosurgery of Pretoria
Medical School. In the recovery room a patient developed a
massive embolization of right carotid artery. He was taken back to
the Operating Room. While an attempt was made to remove emboli,
a new embolization of the left
carotid artery took place. Following all these mishaps, patient was
left with a �locked-in-syndrome�,
total paralysis of all muscles in his body, with the sole exception of
extra-ocular muscles. His neurosurgeon told parents, that the
patient will never breathe on his own, speak or swallow. An intensive
rehabilitation in South Africa for 12 months followed.
When the patient arrived in Germany, his breathing was shallow, he could
not clear his bronchial secretions, could not swallow at all, was able to
say a word only by squeezing the air out his lungs. All muscles in his
body were paralyzed.
Five days after fetal brain cell transplantation the patient was able to
stand up with assistance, cough up his bronchial secretions, speak,
swallow and move his hands(!) Two months later he began his horseback
riding training and could maintain balance in the saddle on his own. His
speech dramatically improved, as well as swallowing and breathing. His
eyesight improved, as to extra-ocular muscles function and accommodation.
In another one month, in May 2005, there was a conference at the medical
school in Pretoria, Alma Mater of the patient, in my honor.
I gave a long lecture about fetal
brain cell transplantation. The discussion afterward was chaired by the
patient. He had to use some technical help to speak in the large
auditorium, like Prof.Dr. Stephen Hawking, but his brain was functioning
perfectly well.
A 46 years old male, a sportsman, from London, UK, in 1993 developed
encephalitis, following which he
lied in bed, motionless. No detailed diagnosis was ever made, no treatment
offered. When he complained about lack of any therapy, he was sent to
psychiatric ward, from where he was taken home by his wife,
against medical advice. After
metabolic preparation, in July 2002, in Kiel, Germany, he
received BCRO intrathecal fetal
brain transplantation. Three months later he was able to move with
assistance and receive intensive physiotherapy program. One year later, he
was able to walk a short distance and to do a self-care in a wheel-chair.
In June 2004 the patient was walking without assistance. He gained weight.
In October 2004, he became the father of a healthy boy.
After my departure from Moscow in 1997 I treated additional patients by
fetal brain cell transplantation in
Germany, Slovakia, Czech Republic, Austria, Italy, Peoples� Republic of
China, South Africa, India, Hong Kong, Indonesia, Turkey, Nigeria, Panama,
Mexico, US, by myself, with following incurable/untreatable medical
problems:
prolonged coma of various etiologies,
incurable/untreatable Parkinson�s disease and
syndrome, amyotrophic lateral
sclerosis,
neurodegenerative
diseases, i.e. multiple sclerosis, Friedreich�s ataxia,
neural muscular atrophies,
Duchenne
and Becker muscular dystrophies,
myasthenia gravis,
cerebrovascular
accidents (stroke), etc.
My first patient in Europe was
an Austrian politician, a friend of my childhood female friend, a
physician. A patient with diabetes
mellitus and a hypertension had 6 months earlier survived a major stroke,
with residual hemiplegia and expressive aphasia. He was depressed due to
his disability and persistent pain due to spasticity. I treated him with
BCRO implantation of 3 different fetal brain cell transplants from rabbits
(from the closed colony). His hemiplegia improved 50% and speech 70%. I
treated also - at the same time � his
diabetes, hypertension by BCRO FCT (from the same rabbits). He was my
first West European patient after leaving Moscow.
In 2007 I treated in Hong Kong a 91 years old man
with Parkinson�s syndrome (the clinical picture of is the same as that
of Parkinson�s disease, but the cause is arteriosclerosis of the Willis
arterial circle at the base of the brain), dementia and depression. I
treated him with the intrathecal fetal brain cells implantation, plus nine
of BCRO FCT�s. In 2 months later, his son reported that 2 weeks ago his
father told his valet to prepare his clothes, because he is going to
casino at night (as that was his favored past time all of his adult life).
There was no way to stop him. He spent most of the night in casino and he
actually made some money! He was acting like 20 years younger. The fact
that he dared to gamble and gambled successfully, was the best proof of
success of his treatment, together with improvement of symptoms of
Parkinson�s syndrome.
In 1988 I treated my medical school classmate,
disabled by multiple sclerosis. She got
the first attack of MS at the age of 26 right after her first pregnancy,
as usually happens in women and in age of 33 she was totally disabled. Her
FCT was done at the age of 56 when she was already terminal. She got
better and wanted to live again to make her husband, a close friend of
mine, happy. She died 20 years later in 2018. � In multiple sclerosis -
under no circumstances - must not be fetal brain cells implanted in the
brain!
Charcot-Marie-Tooth disease (in childhood)
was successfully treated in Austria.
Amyotrophic lateral sclerosis is untreatable
disease, where death will ensue within a few years from the onset. I
treated 4 patients from South Africa.
First
patient was a male, who was treated twice by intrathecal fetal brain cell
transplantation and observed to be well for 3 years.
Second patient was
a male, who received such a treatment once and was well for 2 years.
Third
patient was a female and her ALS was progressing very fast. She was
treated once the same way and her disease stopped for one year.
-
Fourth
patient was a male and his disease progressed even faster than in No. 3.
He was treated once, and his disease stopped for one year. �
I
did not have any further follow-up on all 4 patients.
Muscular dystrophies
� 10 Duchenne and 2 Becker
patients � were treated by IIBM in Moscow and one I treated in Indonesia
by BCRO FCT. The Duchenne patients showed only a minor improvement, while
those with Becker had good result. One patient with Duchenne in Indonesia
was older than patients with Moscow and the result was only mediocre.
Successful treatment of apallic syndrome in 35 children less than 12
years old was accomplished by cell therapy by my teacher Prof.Dr.
Franz Schmid, after the death
of Prof.Dr. Paul Niehans the next king of
zellentherapie. |
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Updated: December 2018 |